Recombinant Human Angiogenin 是一種心血管生成的誘導(dǎo)劑。Angiogenin可能有助于膠質(zhì)瘤的惡性轉(zhuǎn)化以及血管生成過程。
Synonyms
rHuAngiogenin; ANG; RNASE5; Angiogenin ; 重組人血管生成素
Species
HumanSource
E. coli Accession
P03950 Gene ID
283 Molecular Weight
Approximately 14.0 kDa AA Sequence
QDNSRYTHFL TQHYDAKPQG RDDRYCESIM RRRGLTSPCK DINTFIHGNK RSIKAICENK NGNPHRENLR ISKSSFQVTT CKLHGGSPWP PCQYRATAGF RNVVVACENG LPVHLDQSIF RRP Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PBS, 150 mM NaCl, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Angiogenin (rHuAngiogenin) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Angiogenin (rHuAngiogenin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Angiogenin (Ang) is one of the members of the pancreatic ribonuclease (RNase) superfamily that have unusual biological properties. The amino acid sequence of angiogenin revealed that it was homologous to RNase A. It shares 33% sequence identity with the bovine enzyme, including counterparts to the two histidines and one lysine that constitute the catalytic active site. It belongs to the pancreatic RNase superfamily of proteins and is specifically endocytosed by endothelial cells and transported to the nucleus, where it accumulates in the nucleolus. |
