Recombinant Human AG-2, His (HEK293-expressed) 是帶有 N 末端 His 標簽的人重組 AG-2，在 HEK293 細胞中表達。
Synonyms
rHuAG-2, His; HPC8; AGR2; AG2 ; 重組人 AG-2，His (HEK293 細胞表達)
Species
HumanSource
HEK 293 Accession
O95994 Gene ID
10551 Molecular Weight
Approximately 18.0 kDa AA Sequence
RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTELHHHHH H Biological Activity
Data is not available. Appearance
Solution Formulation
Supplied as a 0.2 μm filter solution of 20 mM Tris, 200 mM NaCl, 10% Glycerol, pH 8.0. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
N/A Storage & Stability
Recombinant Human AG-2, His (HEK293-expressed) (rHuAG-2, His) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Shipping with dry ice. Background
AG-2 (Anterior gradient 2) is a human ortholog of the Xenopus laevis cement gland protein and a member of the protein disulfide isomerase (PDI) family. AG-2 is highly expressed and secreted in malignant cancer types, including breast carcinomas, pancreatic cancer, glioblastoma, prostate cancer and metastatic colorectal cancer. AGR2 is also a pro-oncogenic protein that stimulates EGFR ligand amphiregulin, regulate p53 signaling, and interact with the AAA+ protein Reptin. Overexpressed AG-2 stabilizes HIF-1α in tumor cells[1][2]. |
