Recombinant Human Transforming growth factor-beta receptor type 2, C-Fc 是轉(zhuǎn)化生長(zhǎng)因子 β 受體 2 型 (TβRII) 的一個(gè)片段，由 Thr23-Asp159 個(gè)氨基酸組成，C 末端有 Fc 標(biāo)記。
Synonyms
TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II ; 重組人轉(zhuǎn)化生長(zhǎng)因子 β 受體 2 型；C-Fc
Species
HumanSource
HEK 293 Accession
P37173 Gene ID
7048 Molecular Weight
Approximately 59.0 kDa AA Sequence
TIPPHVQKSV NNDMIVTD NN GAVKFPQLCK FCDVRFSTCD NQKSCMSNCS ITSICEKPQE VCVAVWRKND ENITLETVCH DPKLPYHDFI LEDAASPKCI MKEKKKPGET FFMCSCSSDE CNDNIIFSEE YNTSNPD Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, 150 mM NaCl, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Transforming growth factor-beta receptor type 2, C-Fc (HEK293-expressed) (rHuTGF-beta receptor 2, C-Fc) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Transforming growth factor-beta receptor type 2, C-Fc (HEK293-expressed) (rHuTGF-beta receptor 2, C-Fc) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Transforming growth factor-beta receptor type 2 (TβRII) is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain. TβRII is the specific receptor for TGFβ ligands, and crucial for the regulation of TGFβ signaling in tumor initiation, progression, and metastasis[1]. T beta R-II (transforming growth factor beta [TGF-beta] type II receptor) is a transmembrane serine/threonine kinase that acts as the primary TGF-beta receptor. Ligand binding to T beta R-II leads to the recruitment and phosphorylation of T beta R-I, a distantly related transmembrane kinase that acts as a downstream signaling component[2]. |
