Recombinant Human PVR/CD155, His (HEK293-expressed)，是免疫球蛋白超家族中的一種I型跨膜糖蛋白，參與人類動物細胞脊髓灰質(zhì)炎病毒感染和腸道體液免疫反應(yīng)。
Synonyms
rHuPVR/CD155, His; CD155; NECL-5; PVR ; 重組人PVR/CD155, His (HEK293表達)
Species
HumanSource
HEK 293 Accession
P15151 Gene ID
5817 Molecular Weight
50-65 kDa AA Sequence
WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG Y Biological Activity
5 μg/mL (100 μL/well) of immoblized recombinant human PVR/CD155-His can bind human TIGIT-Fc with a linear range of 2.5-10 μg/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human PVR/CD155, His (HEK293-expressed) (rHuPVR/CD155, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human PVR/CD155, His (HEK293-expressed) (rHuPVR/CD155, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily[1]. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. CD155 may also be used to positively select MHC-independent T cells in the thymus[2]. |
