Recombinant Human Keratinocyte Growth Factor/FGF-7, His 是一種多肽有絲分裂原，屬于成纖維細(xì)胞生長(zhǎng)因子家族，只與 FGFR2 的拼接變體 FGFR2 IIIb 結(jié)合，為上皮細(xì)胞特異性的旁泌生長(zhǎng)因子，與其受體在創(chuàng)口愈合過(guò)程中起到重要作用。
Synonyms
rHuKeratinocyte Growth Factor/FGF-7, His; Keratinocyte Growth Factor; Fibroblast Growth Factor-7; HBGF-7 ; 重組人角質(zhì)細(xì)胞生長(zhǎng)因子 1/FGF-7, His 標(biāo)簽
Species
HumanSource
E. coli Accession
P21781 Gene ID
2252 Molecular Weight
Approximately 21.2 kDa AA Sequence
MNHKVHHHHH HMDDDDKMCN DMTPEQMATN VNCSSPERHT RSYDYMEGGD IRVRRLFCRT QWYLRIDKRG KVKGTQEMKN NYNIMEIRTV AVGIVAIKGV ESEFYLAMNK EGKLYAKKEC NEDCNFKELI LENHYNTYAS AKWTHNGGEM FVALNQKGIP VRGKKTKKEQ KTAHFLPMAI LKERIEENGY T Biological Activity
The ED50 is <10 ng/mL as measured by 4MBr-5 cells, corresponding to a specific activity of >1 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Keratinocyte Growth Factor/FGF-7, His (rHuKeratinocyte Growth Factor/FGF-7, His) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Keratinocyte Growth Factor/FGF-7, His (rHuKeratinocyte Growth Factor/FGF-7, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Keratinocyte growth factor 1 or FGF-7 is a polypeptide mitogen that belongs to the family of fibroblast growth factors, binds only to a splice variant of FGFR2 (FGFR2 IIIb) and is a highly specific paracrine growth factor for epithelial cells. FGF-7 and its receptor are believed to be important for normal wound healing[1]. |
