Recombinant Rat Interleukin-3 beta 誘導造血干細胞分化為骨髓前體細胞，如紅細胞、巨核細胞、粒細胞、單核細胞和樹突狀細胞。Recombinant Rat Interleukin-3 beta 也在神經(jīng)系統(tǒng)中發(fā)揮作用，在B-1細胞調(diào)控慢性炎癥疾病中發(fā)揮重要作用。
Synonyms
rRtIL-3β; MCGF; Hematopoietic growth factor; P-cell stimulation factor
Species
RatSource
E. coli Accession
P97688 Gene ID
24495 Molecular Weight
Approximately 16.3 kDa AA Sequence
MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC Biological Activity
The ED50 is <5 ng/mL as measured by NFS-60 cells, corresponding to a specific activity of >2 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat Interleukin-3 beta (rRtIL-3β) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Rat Interleukin-3 beta (rRtIL-3β) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin 3 beta (IL-3 β) is a cytokine that is produced by activated T cells and mast cells. IL-3 β induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. IL-3 β also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases[1]. |
