Recombinant Human Growth Hormone (CHO-expressed) 是一種多肽激素，可刺激生長(zhǎng)、細(xì)胞繁殖和細(xì)胞再生，能用于治療兒童生長(zhǎng)障礙。
Synonyms
rHuGH; Somatotropin; GH-N; GH1 ; 重組人生長(zhǎng)激素 (CHO 細(xì)胞表達(dá))
Species
HumanSource
CHO Accession
P01241 Gene ID
2688 Molecular Weight
20-24 kDa AA Sequence
FPTIPLSRLF DNASLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F Biological Activity
The ED50 is <0.5 ng/mL as measured by murine Balb/c 3T3 cells, corresponding to a specific activity of >2 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Growth Hormone (CHO-expressed) (rHuGH) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Growth Hormone (CHO-expressed) (rHuGH) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Growth Hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the treatment of growth disorders in children[1]. Growth Hormone is a stress hormone that stimulates production of IGF-1 and raises the concentration of glucose and free fatty acids[2]. Growth Hormone exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway[3]. |
