Recombinant Mouse April/TNFSF13 是腫瘤壞死因子 (TNF) 配體家族成員，分子量為 21.9 kDa。
Synonyms
rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256
Species
MouseSource
E. coli Accession
Q9D777 Gene ID
69583 Molecular Weight
Approximately 21.9 kDa AA Sequence
MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL Biological Activity
Full biological activity determined by its ability to induce cell proliferation of RPMI 8226 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM acetic acid. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse April/TNFSF13 (rMuApril/TNFSF13) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Mouse April/TNFSF13 (rMuApril/TNFSF13) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The TNFSF13 gene is located at chromosomal region 17p13.1 and is expressed in various tissues and organs including heart muscle. TNFSF13 is a regulator of the development and function of B cells. TNFSF13 has important roles in normal immune responses, and also in the development of autoimmune and inflammatory diseases. Plasma levels of TNFSF13 are reported to be increased in patients with multiple sclerosis, Sj?gren's syndrome, systemic lupus erythematosus and rheumatoid arthritis. The levels of TNFSF13 are also demonstrated to be significantly higher in the synovial fluid of patients with rheumatoid arthritis than in the serum, suggesting that this protein may be produced locally at the site of inflammation[1]. |
