Recombinant Human WISP-1 是一種能夠促進(jìn)腫瘤細(xì)胞血管生成的 WNT 誘導(dǎo)分泌蛋白。
Synonyms
rHuWISP-1; WNT1-inducible-signaling pathway protein 1; CCN4 ; 重組人源 WNT 誘導(dǎo)分泌蛋白
Species
HumanSource
CHO Accession
O95388 Gene ID
8840 Molecular Weight
44-46 kDa AA Sequence
TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LC Biological Activity
The ED50 is <0.5 μg/mL as measured by ATDC5 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human WISP-1 (CHO-expressed) (rHuWISP-1) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human WISP-1 (CHO-expressed) (rHuWISP-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
WNT-inducible secreted protein-1 (Wisp-1), a matricellular protein that promotes angiogenesis in cancers as well as cell survival in isolated cardiac myocytes and neurons, is a target of HDACs. Further, Wisp-1 transcription is regulated by HDACs and can be modified by the HDAC inhibitor, suberanilohydroxamic acid (SAHA/vorinostat), after MI injury[1]. |
