Recombinant Human VEGF-C (HEK293-expressed) 在淋巴管的生成過(guò)程中發(fā)揮作用，主要通過(guò)其受體VEGFR-3作用于淋巴管內(nèi)皮細(xì)胞，促進(jìn)其生存、生長(zhǎng)和遷移。
Synonyms
rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP ; 重組人源血管內(nèi)皮生長(zhǎng)因子C (HEK293細(xì)胞表達(dá))
Species
HumanSource
HEK 293 Accession
P49767 Gene ID
7424 Molecular Weight
16-19 kDa AA Sequence
MAHYNTEILK SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRR Biological Activity
The ED50 is <0.5 μg/mL as measured by HMVEC human microvascular endothelial cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human VEGF-C (HEK293-expressed) (rHuVEGF-C) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human VEGF-C (HEK293-expressed) (rHuVEGF-C) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration[1]. However, in addition to its effect on lymphatic vessels, it can also promote the growth of blood vessels and regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor VEGFR-2[2]. Apart from vascular targets, VEGF-C is also important for neural development and blood pressure regulation[3][4]. |
