Recombinant Human TWEAK (CHO-expressed) 可以通過多種特異性的細胞死亡通路來誘導(dǎo)凋亡，并能促進內(nèi)皮細胞的增值和遷移，從而調(diào)節(jié)血管生成。
Synonyms
rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L ; 重組人腫瘤壞死因子配體超家族成員12
Species
HumanSource
CHO Accession
O43508 Gene ID
8742 Molecular Weight
20-22 kDa AA Sequence
RKTRARRAIA AHYEVHPRPG QDGAQAGVDG TVSGWEEARI NSSSPLRYNR QIGEFIVTRA GLYYLYCQVH FDEGKAVYLK LDLLVDGVLA LRCLEEFSAT AASSLGPQLR LCQVSGLLAL RPGSSLRIRT LPWAHLKAAP FLTYFGLFQV H Biological Activity
The ED50 is <1 ng/mL as measured by HTB-38 (HT-29) cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human TWEAK (CHO-expressed) (rHuTWEAK) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human TWEAK (CHO-expressed) (rHuTWEAK) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TWEAK is a ligand for the FN14/TWEAKR receptor. TWEAK has overlapping signaling functions with TNF, but displays a much wider tissue distribution. Leukocytes are the main source of TWEAK including human resting and activated monocytes, dendritic cells and natural killer cells[1]. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis[2]. |
