Recombinant Human TRAIL/Apo2L 是一種作為配體的蛋白，通過死亡受體參與誘導(dǎo)細(xì)胞凋亡。
Synonyms
rHuTRAIL/Apo2L; TNFSF10; CD253 ; 重組人腫瘤壞死因子凋亡誘導(dǎo)配體
Species
HumanSource
E. coli Accession
P50591 Gene ID
8743 Molecular Weight
Approximately 19.6 kDa AA Sequence
MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG Biological Activity
The ED50 is <40 ng/mL as measured by RPMI-8226 cells, corresponding to a specific activity of >2.5 × 104 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human TRAIL/Apo2L (rHuTRAIL/Apo2L) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human TRAIL/Apo2L (rHuTRAIL/Apo2L) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Apo2L/TRAIL is one of several members of the TNF gene superfamily that induce apoptosis through engagement of death receptors[1]. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutic. TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension[2]. |
