Recombinant Rat Stromal-Cell Derived Factor-1 alpha/CXCL12 是 CXC 趨化因子家族成員，能夠結(jié)合 CXCR4、CXCR7，與腫瘤的增殖、存活、血管生成、轉(zhuǎn)移及免疫抑制有關(guān)。
Synonyms
rRtSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF ; 重組大鼠基質(zhì)細(xì)胞衍生因子-1α/CXCL12
Species
RatSource
E. coli Accession
Q80YV8 Gene ID
24772 Molecular Weight
Approximately 7.9 kDa AA Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK Biological Activity
Full biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat Stromal-Cell Derived Factor-1 alpha/CXCL12 (rRtSDF-1α/CXCL12) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Rat Stromal-Cell Derived Factor-1 alpha/CXCL12 (rRtSDF-1α/CXCL12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL12 belongs to the CXC chemokine family, and is expressed in two isoforms, SDF-1α and SDF-1β, binds to CXCR4 and CXCR7. CXCL12/CXCR4 signal is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression[1]. |
