Recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 是 CXC 趨化因子家族成員，能夠結(jié)合 CXCR4、CXCR7，與腫瘤的增殖、存活、血管生成、轉(zhuǎn)移及免疫抑制有關(guān)。
Synonyms
rHuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF ; 重組人基質(zhì)細胞衍生因子-1α/CXCL12
Species
HumanSource
E. coli Accession
P48061 Gene ID
6387 Molecular Weight
Approximately 8.0 kDa AA Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Biological Activity
Full biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20-80 ng/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB pH 7.0, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 (rHuSDF-1α/CXCL12) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 (rHuSDF-1α/CXCL12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL12 belongs to the CXC chemokine family, and is expressed in two isoforms, SDF-1α and SDF-1β, binds to CXCR4 and CXCR7. CXCL12/CXCR4 signal is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression[1]. |
