Recombinant Human RANTES/CCL5 (HEK293-expressed) 是一種有效的 CC 趨化因子，在類風(fēng)濕性關(guān)節(jié)炎發(fā)病機(jī)理中具有重要作用。
Synonyms
rHuRANTES/CCL5; C-C motif chemokine 5; SCYA5 ; 重組人 RANTES/CCL5 (HEK293 細(xì)胞表達(dá))
Species
HumanSource
HEK 293 Accession
P13501 Gene ID
6352 Molecular Weight
Approximately 8 kDa AA Sequence
SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS Biological Activity
The ED50 is <0.2 μg/mL as measured by CHO-K1/Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human RANTES/CCL5 (HEK293-expressed) (rHuRANTES/CCL5) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human RANTES/CCL5 (HEK293-expressed) (rHuRANTES/CCL5) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
RANTES/CCL5 is a potent CC chemokine shown to play an important role in rheumatoid arthritis pathogenesis. RANTES/CCL5 primarily attracts lymphocytes and monocytes as well as other cell types. Rheumatoid arthritis synovial fibroblasts produce RANTES/CCL5 upon stimulation with TNF-α, IL-1β, or interferon gamma[1]. |
