Recombinant Human Platelet factor-4/CXCL4 (HEK293-expressed) 是 CXC 趨化因子家族成員，具有抗肝素、抗血管生成的活性，同時可抑制腫瘤新生血管形成。
Synonyms
rHuPF-4/CXCL4; C-X-C motif chemokine 4; Oncostatin A; SCYB4 ; 重組人血小板因子-4/CXCL4 (HEK293 細胞表達)
Species
HumanSource
HEK 293 Accession
P02776 Gene ID
5196 Molecular Weight
Approximately 7.8 kDa AA Sequence
EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES Biological Activity
The ED50 is <10 μg/mL as measured by its ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Platelet factor-4/CXCL4 (HEK293-expressed) (rHuPF-4/CXCL4) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Platelet factor-4/CXCL4 (HEK293-expressed) (rHuPF-4/CXCL4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
PF-4/CXCL4 is a member of the CXC chemokine family produced by cells of the megakaryocytic lineage. CXCL4 has antiheparin activity, responsible for the important role of CXCL4 in the regulation of coagulation processes. CXCL4 has exhibits antiangiogenic properties in vitro and in vivo and inhibits tumor neovascularization through a variety of mechanisms[1]. |
