Recombinant Human PDGF-DD (CHO-expressed) 屬于 PDGF 家族，能夠特異性地結(jié)合并激活其同源受體 PDGFR-β，通過激活多個下游致癌途徑參與調(diào)節(jié)腫瘤增殖、轉(zhuǎn)化和侵襲，導致腫瘤發(fā)展。
Synonyms
rHuPDGF-DD; Platelet-derived growth factor D; SCDGFB ; 重組人血小板衍生生長因子-DD (CHO 細胞表達)
Species
HumanSource
CHO Accession
Q9GZP0 Gene ID
80310 Molecular Weight
19-21 kDa AA Sequence
SYHDRKSKVD LDRLNDDAKR YSCTPRNYSV NIREELKLAN VVFFPRCLLV QRCGGNCGCG TVNWRSCTCN SGKTVKKYHE VLQFEPGHIK RRGRAKTMAL VDIQLDHHER CDCICSSRPP R Biological Activity
The ED50 is <5 μg/mL as measured by 3T3 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human PDGF-DD (CHO-expressed) (rHuPDGF-DD) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human PDGF-DD (CHO-expressed) (rHuPDGF-DD) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
PDGF-DD is a member of the PDGF family, specifically binds to and activates its cognate receptor PDGFR-β, and participates in regulating cancer proliferation, transformation, and invasion through activating multiple downstream oncogenic pathways, resulting in tumor development and progression[1]. |
