Recombinant Human PDGF-CC (HEK293-expressed) 屬于 PDGF 家族，能夠與 PDGFR-α 和 PDGFR-β 結(jié)合，為有效的血管生成因子。
Synonyms
rHuPDGF-CC; PDGF-C; SCDGF ; 重組人血小板衍生生長因子-CC (HEK293 細(xì)胞表達(dá))
Species
HumanSource
HEK 293 Accession
Q9NRA1 Gene ID
56034 Molecular Weight
15-19 kDa AA Sequence
VVDLNLLTEE VRLYSCTPRN FSVSIREELK RTDTIFWPGC LLVKRCGGNC ACCLHNCNEC QCVPSKVTKK YHEVLQLRPK TGVRGLHKSL TDVALEHHEE CDCVCRGSTG G Biological Activity
The ED50 is <1 ng/mL as measured by 3T3 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human PDGF-CC (HEK293-expressed) (rHuPDGF-CC) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human PDGF-CC (HEK293-expressed) (rHuPDGF-CC) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
PDGF-CC is a relatively new member of the PDGF family, abundantly expressed by different types of cells, such as tumor cells, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), pericytes, fibroblasts, and macrophages. PDGF-CC binds to PDGFR-α and PDGFR-β, which are also expressed by many different cell types, including tumor cells, VSMCs, pericytes, and fibroblasts, all of which play important roles in angiogenesis. PDGF-CC is a potent angiogenic factor[1]. |
