Recombinant Human Neurotrophin-4 屬于神經(jīng)營養(yǎng)因子家族中的一員，能夠與兩種不同的受體結(jié)合，高親和性受體 TrkB 和低親和性受體 p75NTR。
Synonyms
rHuNT-4; NT-5; NTF4; NTF5 ; 重組人神經(jīng)營養(yǎng)因子-4
Species
HumanSource
E. coli Accession
P34130 Gene ID
4909 Molecular Weight
Approximately 28.1 kDa AA Sequence
MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A Biological Activity
The ED50 is <5 μg/mL as measured by C6 cells, corresponding to a specific activity of >2.0 × 102 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 50 mM acetic acid. Endotoxin Level
<0.3 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Neurotrophin-4 (rHuNT-4) to 50 μg/mL using ddH2O or 50 mM acetic acid. Storage & Stability
Lyophilized recombinant Human Neurotrophin-4 (rHuNT-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Neurotrophin-4 (NT-4) is a member of the well-studied family of neurotrophins that regulate the development of neuronal networks by participating in the growth of neuronal processes, synaptic development and plasticity, neuronal survival, differentiation, as well as myelination. Neurotrophin-4 binds with two distinct receptors: TrkB, high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR)[1]. |
