Recombinant Human MEC/CCL28 是一種 CC 趨化因子，通過將免疫細胞招募到特定位置，在粘膜免疫系統(tǒng)的分離和區(qū)劃中起關(guān)鍵作用。
Synonyms
rHuMEC/CCL28; C-C motif chemokine 28; SCYA28 ; 重組人 MEC/CCL28
Species
HumanSource
E. coli Accession
Q9NRJ Gene ID
56477 Molecular Weight
Approximately 12.4 kDa AA Sequence
SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY Biological Activity
Full biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 1.0-10.0 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human MEC/CCL28 (rHuMEC/CCL28) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human MEC/CCL28 (rHuMEC/CCL28) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human MEC/CCL28 is a CC chemokine primarily expressed in thymic dendritic cells and mucosal epithelial cells, and plays a key role in the segregation and the compartmentalization of the mucosal immune system through recruitment of immune cells to specific locations. CCL28 also called mucosae-associated epithelial chemokine (MEC), is expressed in most human, mouse and pig mucosal tissues including the salivary gland, mammary gland (MG), small and large intestines and trachea, where it appears to be predominantly produced by epithelial cells[1]. |
