Recombinant Human Monocyte Chemotactic Protein-4/CCL13是CC家族趨化因子，對嗜酸性粒細胞，嗜堿性粒細胞，單核細胞，巨噬細胞，未成熟樹突細胞和T細胞具有化學引誘作用，并且能夠通過其對上皮細胞的作用誘導關(guān)鍵的免疫調(diào)節(jié)反應， 肌肉和內(nèi)皮細胞。
Synonyms
rHuMCP-4/CCL13; C-C motif chemokine 13; MCP4; SCYA13 ; 重組人單核細胞趨化蛋白-4/CCL13
Species
HumanSource
E. coli Accession
Q99616 Gene ID
6357 Molecular Weight
Approximately 8.6 kDa AA Sequence
QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT Biological Activity
Full biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 10-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Monocyte Chemotactic Protein-4/CCL13 (rHuMCP-4/CCL13) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Monocyte Chemotactic Protein-4/CCL13 (rHuMCP-4/CCL13) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CCL13 binds to several chemokine receptors (CCR1, CCR2 and CCR3), allowing it to elicit different effects on its target cells. A number of studies have shown that CCL13 is involved in many chronic inflammatory diseases, in which it functions as a pivotal molecule involved in the selective recruitment of cell lineages to the inflamed tissues and their subsequent activation[1]. |
