Recombinant Human Lymphotactin/XCL1是在感染和炎癥反應(yīng)期間由T，NK和NKT細(xì)胞產(chǎn)生的C類趨化因子。
Synonyms
rHuLymphotactin/XCL1; ATAC; SCYC1 ; 重組人淋巴細(xì)胞趨化因子/XCL1
Species
HumanSource
E. coli Accession
P47992 Gene ID
6375 Molecular Weight
Approximately 10.2 kDa AA Sequence
GSEVSDKRTC VSLTTQRLPV SRIKTYTITE GSLRAVIFIT KRGLKVCADP QATWVRDVVR SMDRKSNTRN NMIQTKPTGT QQSTNTAVTL TG Biological Activity
Full biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 10-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Lymphotactin/XCL1 (rHuLymphotactin/XCL1) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Lymphotactin/XCL1 (rHuLymphotactin/XCL1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
XCL1 is expressed by various immune cells, including activated CD8t T cells, CD4t T cells, NK cells, NKT cells, gd T cells, and thymic medullary epithelial cells. XCL1 elicits its chemotactic function by binding to the receptor called XCR1. XCR1 is expressed by a dendritic cell (DC) subpopulation. The interaction between XCL1 and XCR1 plays an important role in DC-mediated immune response and thymic development of regulatory T cells[1]. |
