Recombinant Human I-TAC/CXCL11 (HEK293-expressed) 是屬于CXC趨化因子家族的細胞因子，其可被IFN-γ及其CXCR3受體強烈誘導(dǎo)。
Synonyms
rHuI-TAC/CXCL11; C-X-C motif chemokine 11; Beta-R1; H174; IP-9; SCYB11 ; 重組人I-TAC/CXCL11 (HEK293表達)
Species
HumanSource
HEK 293 Accession
O14625 Gene ID
6373 Molecular Weight
Approximately 8.3 kDa AA Sequence
FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF Biological Activity
The ED50 is <0.5 μg/mL as measured by CHO-K1/Gα15/hCXCR3 cells (human Gα15 and human CXCR3 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human I-TAC/CXCL11 (HEK293-expressed) (rHuI-TAC/CXCL11) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human I-TAC/CXCL11 (HEK293-expressed) (rHuI-TAC/CXCL11) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). Simultaneous stimulation of fibroblasts or endothelial cells with IFN-γ and interleukin-1β or the TLR3 ligand double-stranded RNA resulted in a synergistic increase of CXCL11 production. CXCL11 attracts activated T-helper 1 (Th1) lymphocytes and natural killer (NK) cells. Like CXCL9 or monokine induced by IFN-γ (Mig) and CXCL10 or IFN-γ–inducible protein-10 (IP-10), CXCL11 signals through CXC chemokine receptor 3 (CXCR3)[1]. |
