Recombinant Mouse IP-10/CXCL10是具有促炎和抗血管生成特性的CXC趨化因子家族的成員
Synonyms
rMuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1 ; 重組小鼠IP-10/CXCL10
Species
MouseSource
E. coli Accession
P17515 Gene ID
15945 Molecular Weight
Approximately 8.7 kDa AA Sequence
IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP Biological Activity
Full biological activity determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 0.1-10.0 ng/ml in the presence of IL-2. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 2× PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse IP-10/CXCL10 (rMuIP-10/CXCL10) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Mouse IP-10/CXCL10 (rMuIP-10/CXCL10) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases[1]. |
