Recombinant Human Interleukin-6 Receptor (CHO-expressed) 負責白細胞介素-6的信號轉導，可能與免疫疾病和各種傳染病有關。
Synonyms
rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80 ; 重組人白細胞介素-6受體 (CHO-表達)
Species
HumanSource
CHO Accession
P08887 Gene ID
3570 Molecular Weight
54-56 kDa AA Sequence
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RL Biological Activity
The ED50 is <0.2 μg/mL as measured by M1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-6 Receptor (CHO-expressed) (rHuIL-6R) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-6 Receptor (CHO-expressed) (rHuIL-6R) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The IL-6 receptor–signaling system is made up of two receptor chains and downstream signaling molecules. The IL-6 receptor (IL-6R) constitutes the IL-6-binding chain, which occurs in two forms, 80 kDa transmembrane and 50-55 kDa-soluble IL-6R (sIL-6R), whereas 130 kDa gp130 constitutes the signal-transducing chain. Both of these proteins belong to the cytokine receptor family with a Trp-Ser-X-Trp-Ser motif[1]. |
