Recombinant Porcine Interleukin-4 (CHO-expressed)是主要的抗炎細(xì)胞因子，參與細(xì)胞增殖，各種基因表達和避免IL-4表達細(xì)胞中的細(xì)胞凋亡。
Synonyms
rPoIL-4; BSF-1; IL4 ; 重組豬白細(xì)胞介素-4 (CHO表達)
Species
PorcineSource
CHO Accession
Q04745 Gene ID
397225 Molecular Weight
Approximately 15 kDa AA Sequence
HKCDITLQEI IKTLNILTAR KNSCMELPVT DVFAAPENTT EKETFCRAST VLRHIYRHHT CMKSLLSGLD RNLSSMANMT CSVHEAKKST LKDFLERLKT IMKEKYSKC Biological Activity
The ED50 is <0.25 ng/mL as measured by TF-1 human erythroleukemic cells, corresponding to a specific activity of >4.0 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Porcine Interleukin-4 (CHO-expressed) (rPoIL-4) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Porcine Interleukin-4 (CHO-expressed) (rPoIL-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells[1]. |
