Recombinant Mouse Interleukin-33是來自IL-1家族的組織來源的核細(xì)胞因子， 在穩(wěn)態(tài)和炎癥期間，均可在內(nèi)環(huán)細(xì)胞，上皮細(xì)胞和成纖維細(xì)胞樣細(xì)胞中大量表達(dá)。
Synonyms
rMuIL-33; Il33 ; 重組小鼠白細(xì)胞介素-33
Species
MouseSource
E. coli Accession
Q8BVZ5 Gene ID
77125 Molecular Weight
Approximately 17.5 kDa AA Sequence
SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI Biological Activity
The ED50 is <0.5 ng/mL as measured by murine D10S cells, corresponding to a specific activity of >2.0 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, and 1 mM EDTA. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Interleukin-33 (rMuIL-33) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Mouse Interleukin-33 (rMuIL-33) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-33 (IL-33) was originally described as an inducer of type 2 immune responses, activating T helper 2 cells and mast cells. Evidence shows that IL-33 also potently stimulates group 2 innate lymphoid cells, regulatory T cells, TH1 cells, CD8+ T cells and natural killer cells[1]. IL-33 is a crucial immune modulator with pleiotropic activities in type-2, type-1 and regulatory immune responses, and important roles in allergic, fibrotic, infectious, and chronic inflammatory diseases[2]. |
