Recombinant Mouse Interleukin-19是白細(xì)胞介素-10家族的成員。 Recombinant Human Interleukin-19的生物學(xué)功能和臨床意義仍待研究。
Synonyms
rMuIL-19; IL19 ; 重組小鼠白細(xì)胞介素-19
Species
MouseSource
E. coli Accession
Q8CJ70 Gene ID
329244 Molecular Weight
Approximately 17.7 kDa AA Sequence
MLRRCLISVD MRLIEKSFHE IKRAMQTKDT FKNVTILSLE NLRSIKPGDV CCMTNNLLTF YRDRVFQDHQ ERSLEVLRRI SSIANSFLCV QKSLERCQVH RQCNCSQEAT NATRIIHDNY NQLEVSSAAL KSLGELNILL AWIDRNHLET PAA Biological Activity
The ED50 is <50 ng/mL as measured by MCF-7 cells, corresponding to a specific activity of >2.0 × 104 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 50 mM acetic acid. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Interleukin-19 (rMuIL-19) to 50 μg/mL using 50 mM acetic acid. Storage & Stability
Lyophilized recombinant Mouse Interleukin-19 (rMuIL-19) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
IL-19 shares 21% amino acid identity with IL-10. The exon/intron structure of IL-19 is similar to that of the human IL-10 gene, comprising five exons and four introns within the coding region of the IL-19 cDNA. IL-19 does not bind or signal through the canonical IL-10 receptor complex[1]. IL-19 functions through a receptor complex composed of IL-20Ra and IL20Rb that is also utilized by IL-20 and IL-24. IL19 has been shown to enhance the production of Th2 cytokines in Tcells and to be elevated in asthma patients. Furthermore, it induces IL-6, IL-8 and IL-10 expression in monocytes. Additionally, it has been implicated in a range of diseases and disorders, including aging, Type-I diabetes, endotoxic shock, periodontal disease, vascular disease and rheumatoid arthritis[2]. |
