Recombinant Human Interleukin-17F 在炎癥反應(yīng)中有多種功能，在一些腫瘤發(fā)生過(guò)程中起保護(hù)作用。
Synonyms
rHuIL-17F; Cytokine ML-1 ; 重組人白細(xì)胞介素-17F
Species
HumanSource
E. coli Accession
Q96PD4 Gene ID
112744 Molecular Weight
Approximately 30.1 kDa AA Sequence
MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ Biological Activity
The ED50 is <20 ng/mL as measured by murine NIH/3T3 cells, corresponding to a specific activity of >5.0 × 104 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.2, with trehalose. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-17F (rHuIL-17F) to 100 μg/mL using 4 mM HCl. Storage & Stability
Lyophilized recombinant Human Interleukin-17F (rHuIL-17F) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Interleukin-17F could induce pulmonary neutrophilia and amplifies antigen-induced allergic response[1]. IL-17F has been shown to have multiple functions in inflammatory responses and plays an important role in the tumorigenesis of human colonic epithelial cells.. Similar to IL-17A, IL-17F induces the production of many pro-inflammatory cytokines (IL-6/GM-CSF) and chemokines (CXCL1/2/5) in different cell types, as well as enhances granulopoiesis and neutrophil recruitment[2]. |
