Recombinant Human Interleukin-1 beta (CHO-expressed) 能調(diào)控炎癥反應(yīng)，參與細(xì)胞增殖、分化、凋亡等多種細(xì)胞生命活動。
Synonyms
rHuIL-1β; Catabolin; IL1F2; IL1B ; 重組人白細(xì)胞介素-1 β (CHO細(xì)胞表達(dá))
Species
HumanSource
CHO Accession
P01584 Gene ID
3553 Molecular Weight
Approximately 17 kDa AA Sequence
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS Biological Activity
The ED50 is <10 pg/mL as measured by D10S cells, corresponding to a specific activity of >1.0 × 108 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-1 beta (CHO-expressed) (rHuIL-1β) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-1 beta (CHO-expressed) (rHuIL-1β) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
IL-1β (Interleukin-1 beta) is a member of the interleukin 1 family of cytokines. IL-1β is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by IL-1β in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity[1]. |
