Recombinant Human GRO gama/CXCL3 通過(guò)與細(xì)胞表面趨化因子受體相結(jié)合作用介導(dǎo)其對(duì)靶細(xì)胞的影響。
Synonyms
rHuGRO-γ/CXCL3; C-X-C motif chemokine 3; MIP2-beta ; 重組人 CXC 趨化因子3
Species
HumanSource
E. coli Accession
P19876 Gene ID
2921 Molecular Weight
Approximately 7.9 kDa AA Sequence
ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN Biological Activity
Full biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of 10-100 ng/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 50 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human GRO gama/CXCL3 (rHuGRO-γ/CXCL3) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human GRO gama/CXCL3 (rHuGRO-γ/CXCL3) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL3 is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2[1]. CXCL3 also regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum[2]. |
