Recombinant Human Fibroblast Growth Factor-7 是一種間充質(zhì)細(xì)胞來(lái)源的旁分泌生長(zhǎng)因子，可特異性刺激上皮細(xì)胞增值和分化。
Synonyms
rHuFGF-7; HBGF-7; KGF ; 重組人成纖維細(xì)胞生長(zhǎng)因子-7
Species
HumanSource
E. coli Accession
P21781 Gene ID
2252 Molecular Weight
Approximately 19.0 kDa AA Sequence
MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT Biological Activity
The ED50 is <2 ng/mL as measured by 4MBr-5 cells, corresponding to a specific activity of >5.0 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor-7 (rHuFGF-7) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Fibroblast Growth Factor-7 (rHuFGF-7) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Fibroblast growth factor-7 (FGF-7) is a mesenchymal cell-derived paracrine growth factor that specifically stimulates epithelial cell proliferation, has been implicated in the repair of lung tissue[1]. FGF7, also known as keratinocyte growth factor, insofar as it displays a unique cell specificity. FGF7 binds to perlecan protein core and that exogenous perlecan efficiently reconstitutes FGF7 mitogenic activity in perlecan-deficient cells[2]. |
