Recombinant Mouse Exodus-2/CCL21 可通過趨化因子受體 CCR7 和 CXCR3 發(fā)揮作用，促進(jìn)纖維化和炎癥細(xì)胞因子的產(chǎn)生。
Synonyms
rMuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21 ; 重組小鼠嗜酸性細(xì)胞趨化因子 (CCL21)
Species
MouseSource
E. coli Accession
P86792 Gene ID
65956 Molecular Weight
Approximately 12.1 kDa AA Sequence
SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG Biological Activity
Full biological activity determined by a chemotaxis bioassay using murine T-lymphocytes is in a concentration range of 10-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Exodus-2/CCL21 (rMuExodus-2/CCL21) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Mouse Exodus-2/CCL21 (rMuExodus-2/CCL21) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CCL21, also known as 6Ckine, TCA4, SLC, Exodus2, and A21, is a 12 kDa homeostatic chemokine that plays an important role in adaptive immune responses and inflammation[1]. Mature mouse CCL21 shares 71% and 84% aa sequence identity with human and rat CCL21, respectively[2]. Expression of the lymphoid chemokine CCL21/SLC is found to be induced in almost all venules surrounded by inflammatory cuffs in brain and spinal cord sections of mice afflicted with active EAE[3]. |
