Recombinant Human Beta Defensin-3 是一種抗菌肽，對(duì)革蘭氏陽性菌和革蘭氏陰性菌均有抗菌活性，具有化學(xué)誘導(dǎo)劑的作用。
Synonyms
rHuBD-3; DEFB-3; HBD3; Beta-defensin 103 ; 重組人 β-防御素-3
Species
HumanSource
E. coli Accession
P81534 Gene ID
55894 Molecular Weight
Approximately 5.2 kDa AA Sequence
GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK Biological Activity
The ED50 is <30 μg/mL as measured by anti-microbial activity against E.coli, corresponding to a specific activity of >33.3 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Beta Defensin-3 (rHuBD-3) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Beta Defensin-3 (rHuBD-3) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human β-defensin-3 (HβD-3) is the most recently discovered member of the host defense peptide family. HβD-3 has been shown to exhibit antibacterial activities towards Gram-negative and Gram-positive bacteria as well as an ability to act as a chemo-attractant. HβD-3 is of special interest for structural and functional studies and also for possible pharmaceutical applications. It is also one among the identified human defensins that has the ability to undergo oligomerization[1]. |
