Recombinant Rat Fibroblast Growth Factor 18 是一種肝素結(jié)合多肽生長因子，在軟骨的生長、成熟，以及功能性軟骨和骨組織的發(fā)育過程中起作用。
Synonyms
rRtFGF-18; zFGF5; FGF18 ; 重組大鼠成纖維細胞生長因子 18
Species
RatSource
E. coli Accession
O88182 Gene ID
29369 Molecular Weight
Approximately 20.1 kDa AA Sequence
EENVDFRIHV ENQTRARDDV SRKQLRLYQL YSRTSGKHIQ VLGRRISARG EDGDKYAQLL VETDTFGSQV RIKGKETEFY LCMNRKGKLV GKPDGTSKEC VFIEKVLENN YTALMSAKYS GWYVGFTKKG RPRKGPKTRE NQQDVHFMKR YPKGQTELQK PFKYTTVTKR SR Biological Activity
The ED50 is <0.5 μg/mL as measured by 3T3 cells, corresponding to a specific activity of > 2.0 × 103 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat Fibroblast Growth Factor 18 (rRtFGF-18) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Rat Fibroblast Growth Factor 18 (rRtFGF-18) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Fibroblast growth factor 18 (FGF18), a secreted heparin-binding polypeptide growth factor, is related to FGF8 and 175 and has been shown to have a number of functions in different organs. FGF18 is involved in cartilage growth and maturation and is implicated in the development of functional cartilage and bone tissue. It is also involved in processes within mature cartilage10-13 as well as being shown to have a role in enhancing regeneration and repair[1]. Fibroblast growth factor 18 (FGF18) acts as an important role in skeletal growth and limb development, potentially through the modulation of osteoblasts, chondrocytes, and osteoclasts[2]. |
