Recombinant Rat Interferon-gamma 是一種促炎性細(xì)胞因子，具有高效的免疫調(diào)節(jié)功能，同時可抗細(xì)胞增殖，抗病毒等?！?BR>Synonyms
rRtIFN-γ; IFNG; IFN-gamma; Interferon gamma ; 重組大鼠干擾素-γ
Species
RatSource
E. coli Accession
P01581 Gene ID
25712 Molecular Weight
Approximately 15.5 kDa AA Sequence
GTLIESLESL KNYFNSSSMD AMEGKSLLLD IWRNWQKDGN TKILESQIIS FYLRLFEVLK DNQAISNNIS VIESHLITNF FSNSKAKKDA FMSIAKFEVN NPQIQHKAVN ELIRVIHQLS PESSLRKRKR SRC Biological Activity
The ED50 is <0.5 ng/mL as measured by WEHI-279 cells, corresponding to a specific activity of >2 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat Interferon-gamma (rRtIFN-γ) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Rat Interferon-gamma (rRtIFN-γ) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interferon-gamma (IFN-γ) is a cytokine with potent immunomodulatory, anti-proliferative, and antiviral properties. IFN-γ activates cells via a different receptor than IFN-α and IFN-β, which accounts for the different physiological properties of the proteins. Production of IFN-γ is largely restricted to activated CD4+ TH1 T cells, CD8+ T cells, and natural killer cells. One of the most important consequences of IFN-γ secretion is the activation of macrophages. In addition, IFN-γ plays a central role in inflammatory responses by activating endothelial cells, promoting TH1 cell development and cellular immune responses, and up-regulation of major histocompatability complex protein expression on antigen-presenting cells[1]. |
