Recombinant Mouse Insulin-like Growth factor-1 是一種促有絲分裂的細(xì)胞因子。
Synonyms
rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I ; 重組小鼠胰島素樣生長(zhǎng)因子-1
Species
MouseSource
E. coli Accession
P05017 Gene ID
16000 Molecular Weight
Approximately 7.8 kDa AA Sequence
MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPTKA A Biological Activity
The ED50 is <10 ng/mL as measured by FDC-P1 cells, corresponding to a specific activity of >1 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Murine Insulin-like Growth factor-1 (rMuIGF-1) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Murine Insulin-like Growth factor-1 (rMuIGF-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice[2]. |
