combinant Human Keratinocyte Growth Factor 1/FGF-7 是一種多肽有絲分裂原，屬于成纖維細胞生長因子家族，只與 FGFR2 的拼接變體 FGFR2 IIIb 結(jié)合，為上皮細胞特異性的旁泌生長因子，與其受體在創(chuàng)口愈合過程中起到重要作用。
Synonyms
rHuKGF-1/FGF-7; Keratinocyte Growth Factor; Fibroblast Growth Factor-7; HBGF-7 ; 重組人角質(zhì)細胞生長因子 1/FGF-7
Species
HumanSource
E. coli Accession
P21781 Gene ID
2252 Molecular Weight
Approximately 19.0 kDa AA Sequence
MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT Biological Activity
The ED50 is <2 ng/mL as measured by 4MBr-5 cells, corresponding to a specific activity of >5.0 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Keratinocyte Growth Factor 1/FGF-7 (rHuKGF-1/FGF-7) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Keratinocyte Growth Factor 1/FGF-7 (rHuKGF-1/FGF-7) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Keratinocyte growth factor 1 or FGF-7 is a polypeptide mitogen that belongs to the family of fibroblast growth factors, binds only to a splice variant of FGFR2 (FGFR2 IIIb) and is a highly specific paracrine growth factor for epithelial cells. FGF-7 and its receptor are believed to be important for normal wound healing[1]. |
