Recombinant Human Interleukin-21 是 1 類細胞因子，由體內(nèi)活化的 CD4+ T 細胞產(chǎn)生。刺激 T 細胞，B 細胞和 NK 細胞增殖與分化 。
Synonyms
rHuIL-21; Za11; IL21
Species
HumanSource
E. coli Accession
Q9HBE4 Gene ID
59067 Molecular Weight
Approximately 15.4 kDa AA Sequence
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS Biological Activity
The ED50 is <0.5 ng/mL as measured by Mino cells, corresponding to a specific activity of >2.0 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-21 (rHuIL-21) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-21 (rHuIL-21) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-21 (IL-21) is a pleiotropic cytokine that has key functions in both the innate and adaptive immunity and the regulation of autoimmunity. IL-21 has a range of activities likely to potentiate antitumor immunoresponses. IL-21 has a role as a single agent in the treatment of melanoma. IL-21 also has significant activity against various types of cancer in combination with monoclonal antibodies or signaling inhibitors[1]. Recombinant human interleukin-21 (rIL-21), a human recombinant interleukin, with Cetuximab, a monoclonal antibody, targeting the epidermal growth factor receptor[2]. |
