Recombinant Human Interferon-lambda1/Interleukin-29 屬于干擾素 λ 家族，具有免疫調(diào)節(jié)作用，能夠抗病毒、抗增殖及抗腫瘤等。
Synonyms
rHuIFN-λ1/IL-29; IL-29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29 ; 重組人干擾素 λ1/白介素-29
Species
HumanSource
E. coli Accession
Q8IU54 Gene ID
282618 Molecular Weight
Approximately 19.8 kDa AA Sequence
GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T Biological Activity
The ED50 is <5 ng/mL as measured by HepG2 cells, corresponding to a specific activity of >2.0 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interferon-lambda1/Interleukin-29 (rHuIFN-λ1/IL-29) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA. Storage & Stability
Lyophilized recombinant Human Interferon-lambda1/Interleukin-29 (rHuIFN-λ1/IL-29) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human Interferon-lambda1/Interleukin-29 is produced by human peripheral blood mononuclear cells (PBMC) and dendritic cells, with antiviral, anti-proliferative and antitumor effects[1]. Human Interferon-lambda1/Interleukin-29 is a member of the interferon lambda family (also known as type III interferons), whose members are distantly related to both the type I interferons and members of the IL-10 family. IFN-λ1 also has important immunoregulatory property, especially with regard to the T helper type 2 (Th2) response[2]. |
