Recombinant Human Interferon-alpha2a 屬于 I 型干擾素，具有免疫調(diào)節(jié)作用，可抗病毒、抗腫瘤。
Synonyms
rHuIFN-α2a; IFNA; IFNA2; IFN-a 2a ; 重組人干擾素-α2a
Species
HumanSource
E. coli Accession
P01563 Gene ID
3440 Molecular Weight
Approximately 19.2 kDa AA Sequence
CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Biological Activity
The ED50 is <0.1 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >1.0 × 107 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interferon-alpha2a (rHuIFN-α2a) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Interferon-alpha2a (rHuIFN-α2a) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human Interferon-α is a cytokine belonging to the type I Interferons (IFNs), acts as a regulatory mediator of the immune response, and also shows antiviral, antitumor activity. IFNsα are used in treatment of hepatitis B and C and in antitumor therapy[1]. Human Interferon-α2 can also be used to treat hairy cell leukemia, chronic myelogenous leukemia, malignant melanoma, follicular lymphoma, condylomata acuminata, and AIDS-related Kaposi sarcoma[2]. |
