Recombinant Human Insulin-like Growth Factor-1 是一種促進(jìn)有絲分裂的細(xì)胞因子，與 IGF 受體結(jié)合，能夠調(diào)節(jié)多種組織的生長，如神經(jīng)組織、淋巴組織、生殖組織、平滑肌、內(nèi)皮細(xì)胞和骨骼等，同時具有調(diào)節(jié)神經(jīng)保護(hù)的作用。
Synonyms
rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I ; 重組人胰島素樣生長因子-1
Species
HumanSource
E. coli Accession
P05019 Gene ID
3479 Molecular Weight
Approximately 7.7 kDa AA Sequence
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Biological Activity
The ED50 is <5 ng/mL as measured by FDC-P1 cells, corresponding to a specific activity of >2.0 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Insulin-like Growth Factor-1 (rHuIGF-1) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Insulin-like Growth Factor-1 (rHuIGF-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice[2]. |
