Recombinant Human Betacellulin 是一種糖蛋白，能夠通過(guò)提高來(lái)自導(dǎo)管和胰腺腺泡細(xì)胞的 β 細(xì)胞的分化和再生來(lái)提高葡萄糖耐受性。
Synonyms
rHuBetacellulin; Probetacellulin; BTC ; 重組人乙胞素因子
Species
HumanSource
E. coli Accession
P35070 Gene ID
685 Molecular Weight
Approximately 15 kDa AA Sequence
MDGNSTRSPE TNGLLCGDPE ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF Y Biological Activity
The ED50 is <0.01 ng/mL as measured by murine Balb/3T3 cells, corresponding to a specific activity of >1.0 × 108 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Betacellulin (rHuBetacellulin) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Betacellulin (rHuBetacellulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Betacellulin (BTC), a member of the epidermal growth factor family, is expressed predominantly in the human pancreas and induces the differentiation of a pancreatic acinar cell line (AR42J) into insulin-secreting cells. Betacellulin binds and activates the EGF receptor (EGFR/erbB-1) and erbB-4, and it induces tyrosine phosphorylation of erbB-2, which couples with the EGFR or erbB-4[1]. |
