4007787550
|
 |
||||||||||||||
| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227179037 | LFA-1a (ITGAL)/CD11a | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【產(chǎn)品類型】Rabbit Monoclonal IgG 【反應(yīng)特異性】Human 【克隆 ID】EP1285Y 【用途】WB , IHC , ICC , FC , IP 【產(chǎn)品性狀】 【陽(yáng)性對(duì)照】 【產(chǎn)品濃度】 【細(xì)胞定位】 【抗原分子量】180 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】In the immune system, integrins have essential roles in leukocyte trafficking a n d function. These include immune cell attachment to endothelial a n d antigen-presenting cells, cytotoxicity, a n d extravasation into tissues (1). Integrin adhesion recept o r s transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation a n d survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial f o r integrin- mediated signaling. JAB1 (Jun activation domain- binding protein 1), a coactivat o r of the c-Jun transcription fact o r , has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer f o r mation a n d n o r mal cell surface expression of these recept o r s, leading to life-threatening bacterial infections (3) WB: 1:20,000 A. Western blot analysis on Jurkat cell lysate B. Immunohistochemical staining of paraffin-embedded |
