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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227179030 | Kv4.2 | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【產(chǎn)品類(lèi)型】Rabbit Monoclonal IgG 【反應(yīng)特異性】Human 【克隆 ID】EP982Y 【用途】WB , IHC , FC 【產(chǎn)品性狀】 【陽(yáng)性對(duì)照】 【產(chǎn)品濃度】 【細(xì)胞定位】 【抗原分子量】80 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) rec o r ded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the p o r e-f o r ming alpha-subunits of the Kv4.x family, are particularly imp o r tant in regulating membrane excitability in the CNS a n d the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current a n d is localized to dendrites a n d cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene a n d a loss of Kv4.2 protein resulted in a specific a n d near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude a n d an increase of concurrent Ca2+ influx (3). WB: 1:1000 A. Western blot analysis on human brain lysate B. Immunohistochemical staining of paraffin-embedded |
