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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227179007 | IRS-2 (IRS2) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【產(chǎn)品類(lèi)型】Rabbit Monoclonal IgG 【反應(yīng)特異性】Human 【克隆 ID】EP903Y 【用途】WB , ICC , IP 【產(chǎn)品性狀】 【陽(yáng)性對(duì)照】 【產(chǎn)品濃度】 【細(xì)胞定位】 【抗原分子量】170 185 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Insulin recept o r substrates (IRS), the maj o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). Sequences of IRS-2 a n d IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain a n d a phosphotyrosine-binding domain, a n d a po o r ly conserved carboxy terminus containing several tyrosine phosph o r ylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, a n d may be essential f o r signaling by several recept o r systems such as insulin a n d cytokine (1). Recommended Applications A. Western blot analysis on 293 + insulin cell lysate |
| 貯存： | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
