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貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
JD1227178981 | IkappaB-alpha Phospho (S32) (NFKBIA) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
性狀: | 【產(chǎn)品類型】Rabbit Monoclonal Antibody 【反應(yīng)特異性】Human 【克隆 ID】EPR3148 【用途】WB , ICC , IP 【產(chǎn)品性狀】 【陽性對照】 【產(chǎn)品濃度】 【細胞定位】 【抗原分子量】40kDa |
質(zhì)量標(biāo)準: | 【產(chǎn)品介紹】The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB-alpha protein (1-5). In response to many different NF-kappaB- inducing agents including T-cell mitogens, proinflammatory cytokines, and viral transactivators, the inhibitory IkappaB-alpha is rapidly phosphorylated and degraded (2). Phosphorylation of IkappaB-alpha at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IkappaB-alpha (3). Activation of NF-kappaB can also be achieved after tyrosine phosphorylation of IkappaBalpha at tyrosine 42, an event that also ultimately leads to the dissociation of NF-kappaB and IkappaBalpha (4). Phosphorylation of IkappaB-alpha at Ser32 and Tyr42 is critical for activation of NF-kappaB, which then translocates to the nucleus and induces transcription of genes that protect organism (1-5). Recommended Applications Western blot analysis on Hela cell lysates Specificity |
貯存: | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |