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【產品介紹】FBNRG3, or Neuregulin 3, is a member of
the neuregulin family. This family consists of ligands
for the transmembrane tyrosine kinase receptors ERBB3
and ERBB4 - members of the epidermal growth factor
receptor family. Ligand binding activates
intracellular signaling cascades and the induction
of cellular responses including proliferation,
migration, differentiation, and survival or
apoptosis. FBNRG3 has been shown to activate
tyrosine phosphorylation of its cognate receptor, ERBB4,
and it is thought to influence neuroblast
proliferation, migration and differentiation by
signaling through ERBB4. FBNRG3 also promotes
mammary differentiation during embryogenesis. Studies
have implicated this protein in schizophrenia
and schizoaffective disorder (1).

Recommended Applications

FC
Applications and Recommended Dilution Factors

FC: 1:100
Species Reactivity

Human

Products Data

Flow cytometric analysis of C6 cells using FBNRG3
RabMAb (DyLight? 488 conjugate, cat.# 4571-1)
(red) compared to a nonspecific negative control
antibody (green).

Specificity

A synthetic peptide corresponding to residues in
the cytoplasmic domain of human FBNRG3 was used as
an immunogen.

貯存：

Storage Condition and Buffer

Store at 2-8° C. PBS (pH 7.2), 0.02% sodium azide,
0.05% BSA. Protect from light. Stable for 6 months from
date of receipt.

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