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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227177714 | DLC8 (N-term) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human , Mouse , Rat 【克隆 ID】EP1660Y 【用途】WB , IHC , ICC , IP 【抗原分子量】10 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】DLC8 protein bound efficiently to gephyrin in in vitro binding assays a n d colocalized with gephyrin during coexpression in HEK293 cells. The binding site f o r DLC8 was mapped to a fragment of 63 amino acids within the central linker domain of gephyrin. In hippocampal neurons, endogenous DLC8 protein was enriched at synaptic sites identified by synaptophysin a n d gephyrin immunostaining. Because DLC8 has been described as stoichiometric components of cytoplasmic dynein a n d myosin-Va complexes, results suggest that mot o r proteins are involved in the subcellular localization of gephyrin (1). DLC8 was identified as a transp o r t molecule in the cytoplasm. DLC8 co-localizes with TRPS1 in dot-like structures in the cell nucleus. In an electroph o r etic mobility shift assay it was shown that the interaction of DLC8 a n d TRPS1 lowers the binding of TRPS1 to the GATA consensus sequence. In addition DLC8 is able to suppress the transcriptional repression activity of TRPS1 (2).
A. Western blot analysis on HeLa cell lysate using B. Immunohistochemical staining of paraffin-embedded |
