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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227177697 | Dab1 Rabbit Antibody | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Mouse , Rat 【克隆 ID】EP2248Y 【用途】WB 【抗原分子量】80 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Disabled-1 (Dab1) regulates laminar o r ganization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abn o r malities in neuronal positioning, migrat o r y behavi o r linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during c o r ticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that co o r dinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adapt o r in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari a n d mdab1 null mice indicate that Reelin a n d Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral c o r tex a n d cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface recept o r s termed very low density lipoprotein recept o r (VLDLR) a n d apolipoprotein E recept o r 2 (ApoER2) (3).
A. Western blot analysis on rat brain lysate using |
